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NRF2 activators (e.g., Bardoxolone Methyl, Sulforaphane) upregulate antioxidant gene programs and have shown promise in IBD and psoriasis

In adults with obesity, along with diet and exercise, Nausea was generally transient 4 Most occurrences of nausea did not lead to permanent discontinuation of Wegovy HD STEP UP: Reported nausea (median duration 6 days) In STEP UP, nausea was reported in all treatment arms and was most prevalent during the dose-escalation period 4 Nausea was not prospectively measured at each patient visit in clinical trials

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10.1093/ajhp/zxz306 6 CalabriaS.RonconiG.DondiL.DondiL.Dell'AnnoI.NordonC.et al (2024)